March 2, 2024


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Vaginal Ring Could Protect Women From HIV for 3 Months

3 min read

TUESDAY, March nine, 2021 (HealthDay News) — A vaginal ring that slowly and gradually releases an antiviral treatment could guard women in opposition to HIV for up to three months, a preliminary trial suggests.

It assessed two formulations of a vaginal ring that releases the antiretroviral dapivirine in the vagina around the course of ninety times. One particular edition contained 100 milligrams (mg) of dapivirine and the other contained 200 mg.

The trial was done at two U.S. web-sites affiliated with the U.S. National Institutes of Overall health-funded Microbicide Trials Community (MTN).

It included 49 healthy HIV-unfavorable women. They were divided into three teams: just one applied the 100 mg dapivirine ring consistently for 13 weeks a 2nd team applied the 200 mg ring consistently for 13 weeks and a third team applied a 30-day ring, replacing it just about every 4 weeks in the course of the analyze period.

All three rings were effectively tolerated by the participants and there were no protection issues. Compared to these with the monthly ring, these with the two ninety-day rings experienced one.three to one.nine times larger concentrations of dapivirine in blood plasma and one.5 to two.nine times larger stages of the drug in vaginal fluid, as effectively as larger concentrations of the drug in cervical tissue.

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The benefits — to be introduced Tuesday at a virtual meeting of the Meeting on Retroviruses and Opportunistic Bacterial infections — propose that the ninety-day ring might give prolonged-acting and sustained HIV safety, according to the researchers. But these types of investigation is viewed as preliminary right until printed in a peer-reviewed journal.

The three-month ring builds on the development by the nonprofit Global Partnership for Microbicides (IPM) of a monthly dapivirine ring, which past calendar year been given a positive view from the European Medicines Company for its use among the women aged eighteen and more mature in developing nations.

Before long just after, the monthly ring was included to the Globe Overall health Corporation checklist of pre-skilled medicines, and previously this calendar year WHO proposed the ring as yet another HIV avoidance selection for women at high possibility of HIV.

IPM is searching for acceptance of the monthly dapivirine ring in jap and southern Africa, and the initially of these conclusions could be designed by mid-calendar year. IPM is also searching for regulatory acceptance of the ring from the U.S. Foodstuff and Drug Administration.


“Regulatory acceptance of the monthly ring would be an outstanding milestone for women, who have been the deal with of the HIV epidemic in much of the entire world and have to have and ought to have to have a vary of safe and helpful approaches,” analyze chair Dr. Albert Liu said in an MTN information launch. He is medical investigation director at the San Francisco Department of Community Overall health.

“With any luck ,, an extended-duration dapivirine ring that women switch just about every three months can be but yet another choice out there to women in the not-too-distant potential,” Liu said.

Extra information

The U.S. Business on Women’s Overall health has a lot more about women and HIV avoidance.

Supply: Microbicide Trials Community, information launch, March nine, 2021 | Newsphere by AF themes.