Optic Nerve Hypoplasia – American Association for Pediatric Ophthalmology and Strabismus
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What is the optic nerve?
The optic nerve is a collection of more than a million nerve fibers that transmit visible signals from the eye to the brain [See Determine 1]. The optic nerve develops all through the 1st trimester of intrauterine life.
Fig. 1: Regular optic nerve.
What is optic nerve hypoplasia?
Optic nerve hypoplasia (ONH) is a congenital issue in which the optic nerve is underdeveloped (small) [See determine two].
Fig. two: Optic nerve hypoplasia.
How is optic nerve hypoplasia diagnosed?
The prognosis of ONH is ordinarily created by the overall look of small/pale optic nerve all through a dilated eye exam. It is difficult to predict visible acuity opportunity centered on the optic nerve overall look.
What causes optic nerve hypoplasia?
Most situations of ONH have no obviously identifiable trigger. There are no identified racial or socioeconomic elements in the advancement of ONH, nor is there a identified affiliation with publicity to pesticides. ONH has been linked with maternal ingestion of phenytoin, quinine, and LSD, as properly as with fetal alcoholic beverages syndrome.
What visible issues are linked with optic nerve hypoplasia?
Vision impairment from ONH ranges from mild to intense and may well influence a single or the two eyes. Nystagmus (shaking of the eyes) may well be noticed with the two unilateral and bilateral situations. The incidence of strabismus is elevated with ONH.
Is optic nerve hypoplasia linked with non-visible issues?
Optic nerve hypoplasia can be linked with central anxious system (CNS) malformations which set the affected individual at hazard for other issues, including seizure disorder and developmental hold off. Hormone deficiencies come about in most youngsters, irrespective of linked midline brain abnormalities or pituitary gland abnormalities on MRI. In fact, most youngsters with expansion hormone deficiency have a ordinary MRI.
What assessments ought to be carried out for youngsters with optic nerve hypoplasia?
An MRI scan is indicated for all youngsters with optic nerve hypoplasia. Analysis by an endocrinologist ought to be mandatory for all individuals beneath five a long time of age.
Does optic nerve hypoplasia get even worse more than time?
In typical, ONH is a steady and nonprogressive issue which does not deteriorate. Vision may well improve a little and nystagmus may well decrease more than time.
Is there any treatment method for optic nerve hypoplasia?
There is no healthcare or surgical treatment method for ONH. Nonetheless, occlusion of the better observing eye may well improve vision in the other eye. Little ones with substantial vision reduction in the two eyes may well gain from early supportive notice by minimal vision experts. Stem mobile treatment method has not been proven to be productive for ONH.
Where by can I find more information and facts pertaining to septo-optic dysplasia?
Backlinks to Content on Stem Mobile Therapy for Optic Nerve Hypoplasia and Other Brain Problems
- Fink C, Garcia-Filion P, Borchert M. “Failure of stem mobile treatment to improve visible acuity in youngsters with optic nerve hypoplasia.” J AAPOS. 2013 Oct 17 (5):490-3. St. Louis Children’s Hospital Press Launch, February eighteen, 2008, “Stem mobile treatment method for youngsters with eye nerve illness known as ‘medical hoax’”.
- Ophthalmology Periods, September 1, 2008 concern, Field News, “Parents warned about ‘medical hoax’ bordering optic nerve hypoplasia. (Ophthalmology Periods E-News, August 1, 2008).
- EyeWorld, January 2009, Sounding the alarm, stem mobile treatment method fraud. Maxine Lipner, Senior EyeWorld Contributing Editor.
- sixty Minutes, September fifteen, 2010, “21st Century Snake Oil”. (Specialist)
- Tychsen L, Lueder G, Stahl, E, Giangiacomo J: Stem mobile treatment does not improve visible perform or structure in youngsters with optic nerve hypoplasia (septo-optic dysplasia). 2010 AAPOS Summary #034. J AAPOS 201014(1) e9.
Updated 09/2019
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