Dehydroepiandrosterone (DHEA) is a hormone that your entire body in a natural way creates in the adrenal gland. DHEA assists make other hormones, including testosterone and estrogen. All-natural DHEA stages peak in early adulthood and then little by little fall as you age.

A artificial version of DHEA is out there as a pill, capsule, powder, topical cream and gel.

Persons use DHEA as an anti-getting older remedy and to boost actual physical overall performance. DHEA is also utilised to take care of depression and indicators of menopause.


Research on DHEA for specific circumstances incorporates:

  • Getting older. In idea, taking DHEA supplements to sustain DHEA stages could gradual the getting older procedure, possibly bettering very well-currently being, cognitive operate and entire body composition. But so far study has not proved this to be genuine. A lot more experiments are desired to better have an understanding of no matter if DHEA supplementation can counteract some of the consequences of getting older. A small study proposed that taking DHEA supplements could possibly boost pores and skin hydration and firmness, and minimize getting older places in elderly older people.
  • Melancholy. DHEA could possibly be a lot more productive at managing depression than placebo, particularly in people today with minimal DHEA stages.
  • Osteoporosis. Examine conclusions on the consequences of DHEA supplementation in the treatment method of osteoporosis are combined. A lot more study is desired to decide no matter if taking DHEA supplements increases bone density in more mature older people with minimal DHEA.
  • Vaginal atrophy. Restricted study implies that DHEA could possibly boost vaginal dryness in postmenopausal females.

Research on the consequences of DHEA on muscle energy and actual physical overall performance had combined outcomes, but most experiments reveal DHEA supplementation has no effect on muscle energy in youthful or more mature older people. The Nationwide Collegiate Athletic Association has banned DHEA use amongst athletes.

DHEA could possibly at some point confirm to have advantages in managing people today identified with specified circumstances, this sort of as adrenal insufficiency and lupus. However, more experiments are desired.

Scientific studies have demonstrated excellent handle of this supplement to generally be minimal.

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Stay away from

Even though some study implies that DHEA could possibly be a little bit practical in managing depression and vaginal atrophy, there is certainly small proof to help anti-getting older promises. Also, DHEA use can result in really serious aspect consequences. Stay away from utilizing this supplement.

Basic safety and aspect consequences

DHEA is a hormone. Use of this supplement could possibly raise stages of androgen and have a steroid effect. DHEA also could possibly raise the chance of hormone-sensitive cancers, including prostate, breast and ovarian cancers. If you have any sort of most cancers or are at chance of most cancers, you should not use DHEA.

Never use DHEA if you happen to be expecting or breastfeeding.

Think about staying away from use of DHEA if you have superior cholesterol or a ailment that impacts the supply of blood to the heart (ischemic heart disorder). DHEA could possibly cut down superior-density lipoprotein (HDL), or “fantastic,” cholesterol stages.

Use of DHEA also could possibly worsen psychiatric diseases and raise the chance of mania in people today who have mood diseases.

DHEA also could possibly result in oily pores and skin, acne and undesirable, male-pattern hair advancement in females (hirsutism).


Achievable interactions include things like:

  • Antipsychotics. Use of DHEA with antipsychotics this sort of as clozapine (Clozaril, Versacloz, others) could possibly cut down the drug’s success.
  • Carbamazepine (Tegretol, Carbatrol, others). Use of DHEA with this drug utilised to take care of seizures, nerve discomfort and bipolar disorder could possibly cut down the drug’s success.
  • Estrogen. Never use DHEA with estrogen. Combining DHEA and estrogen could possibly result in indicators of excessive estrogen, this sort of as nausea, headache and insomnia.
  • Lithium. Use of DHEA with lithium could possibly cut down the drug’s success.
  • Selective serotonin reuptake inhibitors. Use of DHEA with this kind of antidepressant could possibly result in manic indicators.
  • Testosterone. Never use DHEA with testosterone. Combining DHEA and testosterone could possibly result in indicators this sort of as minimal sperm rely and enlarged breasts in males (gynecomastia) and the development of ordinarily male traits in females.
  • Triazolam (Halcion). Making use of DHEA with this sedative could possibly raise the consequences of this drug, causing abnormal sedation and influencing your breathing and heart rate.
  • Valproic acid. Use of DHEA with this medication utilised to take care of seizures and bipolar disorder could possibly cut down the drug’s success.